The Role of Platelet Rich Fibrin for Closure of Oronasal Fistula Post Palatoplasty through Abilities to Keep Growth Factor Activity for a Relatively Longer Period and Stimulate Tissue Regeneration Effectively

Main Article Content

Andi Muh. Octavian Pratama
Anwar Lewa

Abstract

 Oronasal fistula is one of the unfortunate consequences of cleft palate surgery. This can be done after palate surgery in patients with cleft palate, defined as an abnormal connection between the oral and nasal cavities. Multiple systems have attempted that classification. It can be a small, symptomatic or asymptomatic fistula that needs correction. Its speed varies greatly depending on many factors. Both surgical and non-surgical methods (the advantages and disadvantages of each should be considered) are available for correction, and there are combination therapies that help improve surgical outcomes. Platelet-rich fibrin (PRF) is a novel Generation platelet concentrate, very easy to prepare and handle without the use of biochemicals. Its production is dependent on the accumulation of platelets that release cytokines and growth factors. Enriched with growth factors, this hemostatic plug is easy to prepare and operate. Adapted for soft and hard tissue healing. It is used in various fields of dentistry, especially oral and maxillofacial surgery. Reports on the role of PRF in repairing oronasal fistula closure are sparse in the literature, especially in relation to other soft tissue flaps.

Article Details

How to Cite
Pratama, A. M. O., & Anwar Lewa. (2023). The Role of Platelet Rich Fibrin for Closure of Oronasal Fistula Post Palatoplasty through Abilities to Keep Growth Factor Activity for a Relatively Longer Period and Stimulate Tissue Regeneration Effectively . International Journal of Medical Science and Clinical Research Studies, 3(3), 388–393. https://doi.org/10.47191/ijmscrs/v3-i3-20
Section
Articles

References

I. Vyas T, Gupta P, Kumar S, Gupta R, Gupta T, Singh HP. Cleft of lip and palate: A review. Journal of Family Medicine and Primary Care. 2020;9:2621-2625

II. Bykowski MR, Naran S, Winger DG, Losee JE. The rate of oronasal fistula following primary cleft palate surgery: A meta-analysis. The Cleft Palate-Craniofacial Journal. 2015;52:e81-e87

III. Li F, Wang H-T, et al. Cleft relapse and oronasal fistula after Furlow palatoplasty in infants with cleft palate: Incidence and risk factors nt. Journal of Oral and Maxillofacial Surgery 2017;46:275-280. DOI: 10.1016/j.ijom.2016.09.019

IV. Passos et al. Prevalence, cause, and location of palatal fistula in operated complete unilateral cleft lip and palate: Retrospective study. The Cleft Palate–Craniofacial Journal. 2014;51(2):158-164

V. Saluja H DV, Mahindra U. Platelet-rich fibrin: A second generation platelet concentrate and a new friend of oral and maxillofacial surgeons. Ann Maxillofac Surg 2011;1:53-7.

VI. Ghanaati S, Herrera-Vizcaino C, Al-Maawi S, Lorenz J, Miron RJ,Nelson K, et al. Fifteen years of platelet rich fibrin in dentistry and oromaxillofacial surgery: How high is the level of scientific evidence? J Oral Implantol 2018;44:471-92.

VII. Kapse S, Surana S, Satish M, Hussain SE, Vyas S, Thakur D. Autologous platelet-rich fibrin: Can it secure a better healing? Oral Surg Oral Med Oral Pathol Oral Radiol 2019;127:8-18.

VIII. D. M. Dohan, J. Choukroun, A. Diss et al., “Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part III: leucocyte activation: a new feature for platelet concentrates?”

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology, vol. 101, no. 3, pp. E51–E55.

IX. M. W. Mosesson, K. R. Siebenlist, and D. A. Meh, “The structure and biological features of fibrinogen and fibrin,” Annals of the New York Academy of Sciences, vol. 936, pp. 11–30.

X. J. Choukroun, A. Diss, A. Simonpieri et al., “Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part IV: clinical effects on tissue healing,” Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology, vol. 101, no. 3, pp. E56–E60.

XI. Masuki H, Okudera T, Watanebe T, et al. Growth factor and pro-inflammatory cytokine contents in platelet-rich plasma (PRP), plasma rich in growth factors (PRGF), advanced platelet-rich fibrin (A- PRF), and concentrated growth factors (CGF). Int J Implant Dent 2016;2(1):1–6.

XII. M. Kawamura and M. R. Urist, “Human fibrin is a physiologic delivery system for bone morphogenetic protein,” Clinical Orthopaedics and Related Research, no. 235, pp. 302–310.

XIII. V. Nehls and R. Herrmann, “The configuration of fibrin clots determines capillary morphogenesis and endothelial cell migration,” Microvascular Research, vol. 51, no. 3, pp. 347–364.

XIV. H. F. Dvorak, V. S. Harvey, P. Estrella, L. F. Brown, J. McDonagh, and A. M. Dvorak, “Fibrin containing gels induce angiogenesis. Implications for tumor stroma generation and wound healing,” Laboratory Investigation, vol. 57, no. 6, pp. 673–686.

XV. D. Loike, B. Sodeik, L. Cao et al., “CD11c/CD18 on neutrophils recognizes a domain at the N terminus of the A

Most read articles by the same author(s)